[Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 tumors].
ZNF342 expression is specifically decreased in primary oligodendrogliomas and up-regulated in glioma cell lines treated with a demethylating agent, whereas the expression level of the adjacent gene, Gemin7, is not consistently altered in these samples.
ZDHHC18 and ZDHHC23 could target the glioma stem cells of different GBM subsets in the context of their specific niches and regulate the cellular plasticity of these subtypes.
Yet, it is necessary to conduct future prospective explorations to gain a better insight into the impact of XRCC1Arg399Gln polymorphism on glioma risk.
XBP1 confers an important role in protection against oxidative stress in gliomas, potentially via up-regulation of antioxidant molecules such as catalase.
WT CALCR, but not the mutant versions, inhibited Ras-mediated transformation of immortalized astrocytes <i>in vitro</i> Furthermore, calcitonin inhibited patient-derived neurosphere growth and <i>in vivo</i> glioma tumor growth in a mouse model.<b>Conclusions:</b> We demonstrate CT-CALCR signaling axis is an important tumor suppressor pathway in glioma and establish CALCR as a novel therapeutic target for GBM.<i></i>.
WT CALCR, but not the mutant versions, inhibited Ras-mediated transformation of immortalized astrocytes <i>in vitro</i> Furthermore, calcitonin inhibited patient-derived neurosphere growth and <i>in vivo</i> glioma tumor growth in a mouse model.<b>Conclusions:</b> We demonstrate CT-CALCR signaling axis is an important tumor suppressor pathway in glioma and establish CALCR as a novel therapeutic target for GBM.<i></i>.